What causes testosterone deficiency?

As you may know, testosterone is mainly produced in the testicles (testes). However, production is controlled by chemical signals generated in the pituitary and the hypothalamus in the brain. The cause of testosterone deficiency can thus lie either in the testes or in the hypothalamic-pituitary system.

There are several contributing factors to low testosterone levels. We know today that in men there is a slow but steady decline in the blood levels of testosterone with increasing age. Furthermore, a general age-related deterioration in health as a result of disease is often an additional factor in this development. Additionally, the developing testosterone deficiency itself has a negative effect on health and can contribute to the ageing processes.

A low testosterone level can even be present at birth (eg: Klinefelter’s Syndrome). Testosterone levels can also decline prematurely as a result of other diseases or even accidents. In addition, genetically impaired androgen androgen receptors to which testosterone is unable to bind will lead to symptoms of testosterone deficiency.

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